Previously brokers were limited to submitting applications in London and the South East.
The changes apply to both residential and buy-to-let applications.
Charles Morley, head of mortgage distribution, Metro Bank, said: “This is an exciting development for Metro Bank, and for our broker partners and customers.
“Extending our lending area to cover the whole of England and Wales is a direct response to the conversations we’ve had with intermediaries, and we’re confident that it will be a positive development for our partners.
“We’re constantly innovating to meet our customers’, and broker partners’ needs, and are looking forward to bringing the Metro Bank model of service and convenience to many more people across England and Wales.”